BMC Genomics: The gene "jumps" and jumps out of esophageal cancer
July 15, 2015 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Scientists at the University of Cambridge Cancer Research Centre have recently discovered that in more than three-quarters of cases of esophageal cancer, there are "jumping genes" that increase genetic disruption. They used cutting-edge technology to read the DNA profiles of 43 esophageal tumors and blood samples and analyzed the extent of jumps in these mobile genetic sequences. The study was published in the recent BMC Genomics .
The "jumping gene", called the L1 element, can be uprooted by itself and moved into a new DNA sequence, sometimes accidentally jumping into genes that control cell growth. The main author of this article, Professor Paul Edwards, said: "These jumping genes are much more excited in cancer cells than in normal cells." The researchers used the sequence of tumor samples by Paired-end sequencing. The method matches the anomaly in the sequence with the reference genome. The evidence they found showed that the jump occurred on average about 100 times in each tumor sample, and it even occurred 700 times in some tumors. If you jump at or near important genes that control cell growth, serious consequences can occur: changing the normal work of the gene, causing cell growth and division to go out of control can lead to cancer.
Professor Kat Arney of the British Cancer Research Center commented: "Esophageal cancer is the most difficult cancer to treat, and we are working on funding more research to find out the root cause. This new discovery reveals more about genetic information confusion. The relationship with esophageal tumors may one day help develop better ways to diagnose, treat and monitor the disease."
Studies have shown that enhanced hopping activity also occurs in lung and intestinal cancers. So understanding why and how cells do this is critical and perhaps related to new ways of treating cancer.
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