Researchers at the University of Chicago School of Medicine found that the combination of grapefruit juice and anticancer drugs has more than triple the dose of similar anticancer drugs. It also helps patients to avoid the side effects associated with large doses of anticancer drugs and can reduce medical expenses.
It is believed that grapefruit juice can organize certain enzymes in the intestine (these enzymes will decompose certain drugs), allowing more drugs to enter the bloodstream. Therefore, doctors often advise patients not to eat grapefruit when taking certain drugs. Doing so can cause serious side effects or overdose.
The head of the new study, Dr. Isla Cohen, said that grapefruit can significantly increase the level of many drugs in the blood. For a long time, this has been considered a great danger of overdose. The new study aims to explore the feasibility of using grapefruit juice to increase the efficacy of sirolimus. The drug, also known as rapamycin, is a drug that prevents organ transplant rejection and is an anti-cancer drug.
The latest findings show that drinking 8 ounces of grapefruit juice daily can increase the efficacy of sirolimus by 350%. Ketoconazole slows drug metabolism and increases sirolimus by 500%. Scientists say that after several hours of grapefruit juice, its effect on intestinal enzymes begins to play, and the effect lasts for several days.
Dr. Cohen and his colleagues organized three simultaneous sirolimus trials. 138 incurable cancer patients were treated with sirolimus, sirolimus + ketoconazole, and sirolimus + grapefruit juice.
The optimal dose for sirolimus treatment is approximately 90 mg per week. However, if the dose exceeds 45 mg, it will cause serious stomach problems such as nausea and diarrhea. Therefore, only patients taking sirolimus will be taken twice a week for 45 mg. The optimal drug doses for the other two groups were relatively lower. Patients in the “sirolimus + ketoconazole†group only needed 16 mg of sirolimus per week. Patients in the "Sirolimus + Grapefruit Juice" group need to take 25-35 milligrams of sirolimus per week.
Experts cautioned that before taking medications, be sure to carefully read warnings about adverse side effects of drugs and specific foods to prevent accidents. When the situation is not clear, you should ask the doctor.
L-serine, as a basic amino acid of protein, is widely used in medicine, food, cosmetics and other industries. At present, the global market demand for L-serine is 10000t / A. L-serine is a non essential amino acid, which is an important precursor involved in the synthesis of intracellular biological substances such as purine, pyrimidine and phospholipid. L-serine is a raw material for compound amino acid infusion, and can also be used as a raw material for light chemical industry . In addition, L-serine is widely used in advanced cosmetics at home and abroad because of its special wettability and moisture retention
D-serine is one of the most important D-type amino acids in mammals, which is about 1 / 3 of the total free serine. It has been found that high concentration of D-serine exists in the higher center of higher animals, including human beings, and it plays an important role in neurotransmitter. It is found that D-serine plays an important role in the corpus cavernosum and lower esophageal sphincter of mice.
L-Cystine Powder,L-Serine Powder,L-Serine Manufacture,L-Cystine Manufacture
Xi'an Tian Guangyuan Biotech Co., Ltd. , https://www.tgybiotech.com