There are many clinical trials currently underway in the world (including first to third generation CAR). In addition to CD19, what other targets are used for CAR-T treatment of tumors? Today, Xiao Bian makes a comprehensive summary of the targets used in CAR-T clinical use, the corresponding tumor types, receptor types, and the generations of CAR technologies used, and hopes to have reference significance for wheat flour.
CAR-T (chimeric antigen receptor T cell immunotherapy), a new type of cell therapy that has been used for many years but has been improved and used clinically in recent years. It has significant efficacy in the treatment of acute leukemia and non-Hodgkin's lymphoma and is considered to be one of the most promising treatments for cancer.
Due to the high sensitivity of CAR-T therapy, its targeted/off-target toxicity leads to more serious side effects than traditional antibody drugs. Therefore, the target selection of CAR-T therapy cannot be applied to the target selection criteria of traditional antibody therapy, but it is necessary to find a more stringent tumor-specific antigen as a target.
Needless to say, the most successful case of CAR-T is a series of clinical trials targeting B cell tumors targeting CD19. Clinical trials have shown that CD19 CAR-T has a cure rate of 90% for acute B-lymphocytic leukemia (B-ALL).
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