The subcutaneous implant device can detect metastatic cancer cells early!

Release date: 2016-09-20

A small device implanted under the skin can improve the survival rate of breast cancer patients by capturing cancer cells, slowing the development of metastatic cancer cells in other organs, and gaining time for surgery or other treatments.

 

These findings, published in Cancer Research, provide a way to identify metastatic cancer early and to intervene to improve outcomes.

 

The study, which was conducted in mice, extended the team's early findings that the implantable stent device was effective in capturing metastatic cancer cells. Here, the researchers improved their equipment and showed that the survival rate was improved before surgery was performed before the first signs of metastatic cancer.

 

This device is made of FDA approved materials. This material is commonly used in human sutures and wound dressings. It can be biodegraded and can last up to two years in a patient. The investigators envisioned implanting it under the skin for non-invasive imaging monitoring. Once the cancer cells are found to be showing signs of being settled, they are removed and tested for a fixed point.

 

It is designed to mimic the environment in which cancer cells migrate to other organs. The device can attract immune cells in the body and immune cells in cancer cells. This then limits the transfer of cancer cells to the lungs, liver, and brain, which usually spread to these organs.

 

"Typically, immune cells initially colonize the metastatic site and then pave the way for cancer cells to spread to the organ. Our findings suggest that implanting immune cells into the device limits immune cells, making them difficult to cancer. The cell transfer is ready. The more immune cells in the device, the more cancer cells can be attracted," said Shea.

Source: Noble

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