Release date: 2014-06-16
The blood vessels are twisted and twisted in our body. They bear the function of transporting the necessary nutrients to discharge toxic waste, and escort the normal work of our organs. It has been a long-term problem to develop new artificial blood vessels. Recently, from Brigham and Women's Hospital. Scientists have successfully constructed artificial blood vessels by using 3D printing technology, and the related research results are published in the international magazine Lab on a Chip.
Bioengineer Dr. Ali Khademhosseini said that in recent years we have achieved incredible results in the manufacture of complex artificial tissues such as artificial heart, liver and lungs, but the development of artificial blood vessels remains a key challenge in tissue engineering. Researchers have attempted to conduct in-depth research by developing special vascular hydrogel structures in conjunction with 3D printing technology.
In this study, the researchers first developed an agarose fiber template as a template for an artificial blood vessel using a 3D bioprinter, followed by a hydrogel to cover the template to form a casting mold, which was finally reinforced by cross-linking techniques; With this new technology, researchers have successfully built a microchannel network that can exhibit architectural properties, and then hydrogels can be used to fill microchannels, such as methacrylate gelatin or hydrogels based on different concentrations. Polymer.
Methacrylate gelatin can be filled with cells, which can reveal the function of the connected vascular network to improve large cell transport, cell viability, and cell differentiation. Finally, researchers say that future 3D printing technologies will be used to develop A portable, customized organization of patients, or the development of safe and effective drugs for the treatment of various diseases.
Source: Translational Medicine Network
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