After many years of exploration, Brazilian scientists have recently developed a simple method for early detection of the risk of breast cancer recurrence and have been put into clinical use at the St. Paul's Cancer Hospital.
According to the "São Paulo" reported on the 26th, the human body's p53 gene can detect DNA (DNA) replication errors and prevent the occurrence of erroneous cell division, and c-erbB-2 gene can promote cell proliferation. By detecting the activity of these two genes in the tumor, it is possible to accurately predict early postoperative recurrence of breast cancer.
Genes control the synthesis of proteins, so the activity of proteins also reflects the genetic activity that determines the protein. The new method invented by Brazilian scientists does not directly detect genes, but rather detects genes that are more easily detected and controlled by genes. Therefore, it is very simple and can be performed in general laboratories.
The researchers used this technique to perform experiments on 156 breast cancer patients. The tumor diameters of these patients were all less than 2 cm. No cancer cells metastasized when they were removed. After 50 months, 87.7% of those patients whose tumors had excessively high levels of activity in these tumors relapsed, and 43.3% of them died. In these two patients with normal gene activity, the recurrence rate and mortality were only 10.1% and 10.6%.
The researchers pointed out that this technology allows doctors to take appropriate treatment measures according to the different conditions of the patient as soon as possible, which has important clinical significance. The incidence of breast cancer in Brazil is high, killing 17,000 women every year.
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