Japanese researchers have recently developed a new technology for the delivery of tiny capsules for pancreatic cancer. Animal experiments have demonstrated the effectiveness of this technology.
Researchers at the University of Tokyo reported that they used tiny capsules made of macromolecules to block chemotherapeutic drugs and injected them into mice transplanted with human pancreatic cancer tissue. As a result, the drugs were successfully delivered to cancerous sites, and they successfully suppressed the proliferation of cancer cells.
According to reports, there are holes in the capillaries of tumors. After the microcapsules enter the blood vessels as they enter the bloodstream, they can leak into the blood vessels through the small holes and enter the cancer cells to release drugs. The capsules will hardly enter the unrelated organs and cause side effects. This technology has been used for the treatment of ovarian cancer. However, due to the smaller pores in the blood vessel walls of pancreatic tumors, capsules of 100 nanometers (one nanometer equals one billionth of a meter) commonly used for this therapy are difficult to leak out, and the interstitial tissue between the blood vessels and cancer cells can interfere with capsules. The move caused the drug to be delivered unsuccessfully.
To this end, researchers have developed new capsules that are only 30 nanometers in size. After being injected into the mice, the capsules were able to pass through the blood vessel wall and interstitium, accumulate around the cancer cells, and release the drug for several days. The researchers continued to observe the mice for 16 days and found no cancer cell proliferation.
The researchers said that because the capsule is very small, it can easily leak out of the blood vessels of the pancreatic tumor and has a strong penetration, so it is easier to focus around the pancreatic cancer tissue. New technologies are expected to improve the therapeutic effects of pancreatic cancer.
The research report was published in the online edition of the new issue of Nature Nanotechnology magazine.
Researchers at the University of Tokyo reported that they used tiny capsules made of macromolecules to block chemotherapeutic drugs and injected them into mice transplanted with human pancreatic cancer tissue. As a result, the drugs were successfully delivered to cancerous sites, and they successfully suppressed the proliferation of cancer cells.
According to reports, there are holes in the capillaries of tumors. After the microcapsules enter the blood vessels as they enter the bloodstream, they can leak into the blood vessels through the small holes and enter the cancer cells to release drugs. The capsules will hardly enter the unrelated organs and cause side effects. This technology has been used for the treatment of ovarian cancer. However, due to the smaller pores in the blood vessel walls of pancreatic tumors, capsules of 100 nanometers (one nanometer equals one billionth of a meter) commonly used for this therapy are difficult to leak out, and the interstitial tissue between the blood vessels and cancer cells can interfere with capsules. The move caused the drug to be delivered unsuccessfully.
To this end, researchers have developed new capsules that are only 30 nanometers in size. After being injected into the mice, the capsules were able to pass through the blood vessel wall and interstitium, accumulate around the cancer cells, and release the drug for several days. The researchers continued to observe the mice for 16 days and found no cancer cell proliferation.
The researchers said that because the capsule is very small, it can easily leak out of the blood vessels of the pancreatic tumor and has a strong penetration, so it is easier to focus around the pancreatic cancer tissue. New technologies are expected to improve the therapeutic effects of pancreatic cancer.
The research report was published in the online edition of the new issue of Nature Nanotechnology magazine.
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