Key words: sodium alginate preparation
A sodium alginate polysaccharide compound, which is obtained by extracting a rare alkali from brown algae. It is soluble in water of different temperatures and soluble in ethanol, ether and other organic solvents; the viscosity of different molecular weight products is different. Calcium alginate is insoluble in water and can be solidified into a capsule by calcium chloride. Sodium alginate is stable, non-toxic, film-forming or spheroidal, and is a commonly used capsule material and carrier material.
1 sustained release
Propafenone hydrochloride was used as a model drug to compare the sustained release and release characteristics of sodium alginate, chitosan and the mixture of the two. The results showed that the sustained release of sodium alginate and chitosan was good, and the release rate was less affected by the pH of the transmitter. When the ratio of the two was 1:1 or 3:2, the sustained release tablets were in artificial gastric juice. It is similar to the release law in artificial intestinal fluid. The propofol hydrochloride, diltiazem hydrochloride and isosorbide dinitrate were used as model drugs to study the release of sodium alginate skeleton tablets with different molecular weights. The results showed that there was a good linear relationship between the molecular weight of sodium alginate and the release rate. According to this relationship, the release of sodium alginate with known molecular weight can be predicted, which provides a theoretical basis for the formulation design and practical application of sodium alginate sustained-release tablets.
2 wrapping and coating
Wrapped with fetal pituitary cells plus 2.2% sodium alginate. After 6 days of culture, the microcapsules were transplanted into the abdominal cavity of rabbits. The microcapsules were removed from the abdominal cavity free of each week and their morphology was observed under a microscope. The results showed that the microcapsules were intact and the activity of the cells in the capsules was good during the 12-week observation period, suggesting that the micro-pituitary cells could survive for >12 weeks after transplantation. In order to rapidly prepare microencapsulated suckling pig islet cells that meet practical requirements, the influence of key factors on the preparation of microcapsules has been studied. The results showed that the concentration of sodium alginate and the ratio of islet cells and sodium alginate had a great influence on the microcapsules. The concentration of 1.5%-2.0% and the ratio of 1:8-1:10 were used to prepare microencapsulated suckling pig islet cells. Under suitable conditions, the obtained microencapsulated islet cells have good biological activity. The microcapsules prepared with 3% sodium alginate and 2.2% calcium chloride showed no rupture under the impact of high flow rate and high concentration of sucrose solution, and the microcapsules wrapped the living cells after 2 hours of vigorous stirring, and did not leak. The microcapsules prepared by the improved method have good mechanical strength, and the physical properties thereof meet the requirements for clinical treatment of diabetic islets with islet transplantation. Zhang Lehong reported that sodium alginate-polylysine-alginate biomicrocapsules (APA microcapsules) were used to microencapsulate newborn pig islet cells as a source of xenograft donors. The microencapsulated cells were used to coat the neonatal porcine islet cells, and the insulin content in the culture medium was measured by radioimmunoassay. The insulin secretion and insulin release test of microencapsulated and unmicroencapsulated neonatal porcine islet cells were compared. Histological examination, results 2 The difference was not significant and both had good bioactive secretion ability. Microencapsulated neonatal porcine islet xenografts reversed the hyperglycemia status of diabetic rats for up to 235 days. There were no diabetic cataracts and glomerular basement membrane changes in the early early isotope transplanted rat, but cataract and glomerular base appeared in the untransplanted and non-microencapsulated islet transplantation groups 2 to 3 months later. Membrane changes, microcapsules can effectively protect the graft in vivo survival, and have a good therapeutic and preventive effect on rat diabetes and its complications. Li Wuming used surface cross-linking surgery to microencapsulate active bifidobacteria, and the microcapsule effect prepared by using chitosan/alginate as a capsule material was good. The microcapsules still retain high activity and continue to proliferate in the microcapsules. The acid-resistant microencapsulation technology is promising for use in novel microecological preparations.
A sodium alginate polysaccharide compound, which is obtained by extracting a rare alkali from brown algae. It is soluble in water of different temperatures and soluble in ethanol, ether and other organic solvents; the viscosity of different molecular weight products is different. Calcium alginate is insoluble in water and can be solidified into a capsule by calcium chloride. Sodium alginate is stable, non-toxic, film-forming or spheroidal, and is a commonly used capsule material and carrier material.
1 sustained release
Propafenone hydrochloride was used as a model drug to compare the sustained release and release characteristics of sodium alginate, chitosan and the mixture of the two. The results showed that the sustained release of sodium alginate and chitosan was good, and the release rate was less affected by the pH of the transmitter. When the ratio of the two was 1:1 or 3:2, the sustained release tablets were in artificial gastric juice. It is similar to the release law in artificial intestinal fluid. The propofol hydrochloride, diltiazem hydrochloride and isosorbide dinitrate were used as model drugs to study the release of sodium alginate skeleton tablets with different molecular weights. The results showed that there was a good linear relationship between the molecular weight of sodium alginate and the release rate. According to this relationship, the release of sodium alginate with known molecular weight can be predicted, which provides a theoretical basis for the formulation design and practical application of sodium alginate sustained-release tablets.
2 wrapping and coating
Wrapped with fetal pituitary cells plus 2.2% sodium alginate. After 6 days of culture, the microcapsules were transplanted into the abdominal cavity of rabbits. The microcapsules were removed from the abdominal cavity free of each week and their morphology was observed under a microscope. The results showed that the microcapsules were intact and the activity of the cells in the capsules was good during the 12-week observation period, suggesting that the micro-pituitary cells could survive for >12 weeks after transplantation. In order to rapidly prepare microencapsulated suckling pig islet cells that meet practical requirements, the influence of key factors on the preparation of microcapsules has been studied. The results showed that the concentration of sodium alginate and the ratio of islet cells and sodium alginate had a great influence on the microcapsules. The concentration of 1.5%-2.0% and the ratio of 1:8-1:10 were used to prepare microencapsulated suckling pig islet cells. Under suitable conditions, the obtained microencapsulated islet cells have good biological activity. The microcapsules prepared with 3% sodium alginate and 2.2% calcium chloride showed no rupture under the impact of high flow rate and high concentration of sucrose solution, and the microcapsules wrapped the living cells after 2 hours of vigorous stirring, and did not leak. The microcapsules prepared by the improved method have good mechanical strength, and the physical properties thereof meet the requirements for clinical treatment of diabetic islets with islet transplantation. Zhang Lehong reported that sodium alginate-polylysine-alginate biomicrocapsules (APA microcapsules) were used to microencapsulate newborn pig islet cells as a source of xenograft donors. The microencapsulated cells were used to coat the neonatal porcine islet cells, and the insulin content in the culture medium was measured by radioimmunoassay. The insulin secretion and insulin release test of microencapsulated and unmicroencapsulated neonatal porcine islet cells were compared. Histological examination, results 2 The difference was not significant and both had good bioactive secretion ability. Microencapsulated neonatal porcine islet xenografts reversed the hyperglycemia status of diabetic rats for up to 235 days. There were no diabetic cataracts and glomerular basement membrane changes in the early early isotope transplanted rat, but cataract and glomerular base appeared in the untransplanted and non-microencapsulated islet transplantation groups 2 to 3 months later. Membrane changes, microcapsules can effectively protect the graft in vivo survival, and have a good therapeutic and preventive effect on rat diabetes and its complications. Li Wuming used surface cross-linking surgery to microencapsulate active bifidobacteria, and the microcapsule effect prepared by using chitosan/alginate as a capsule material was good. The microcapsules still retain high activity and continue to proliferate in the microcapsules. The acid-resistant microencapsulation technology is promising for use in novel microecological preparations.
Black Light
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Black Light
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