The sixth affiliated hospital of Sun Yat-sen University claimed on June 1 that the world’s first “mitochondria transplanted baby†had been discharged in the near future. This new technology helps a primary infertile mother to successfully conceive.
Xiaomei (a pseudonym), who is already 30 years old, has a very good relationship with her husband but has never had a child. After the examination, she was informed that she had primary infertility and bilateral fallopian tube disease.
According to Liang Xiaoyan, director of the Reproductive Medicine Center of the Sixth Hospital Affiliated to Sun Yat-sen University, primary infertility refers to women who have sex, and have not had any pregnancy or miscarriage and have not been able to conceive without taking contraceptive measures. 1 year limit.
There are many factors that cause primary infertility, both partners have the possibility of existence, male factors are abnormal semen, sexual dysfunction, immune factors. Female factors have ovulation disorders, tubal factors, uterine factors.
After undergoing two failed IVF treatments, Liang Xiaoyan teamed up with the team of Liu Xingguo, a researcher at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences to use the oocyte injection to overcome the problem of primary infertility. "Automated bone marrow cell mitochondrial" technology, for the small US to improve the quality of embryos, so that the mother successfully conceived, and finally the birth of the world's first "mitochondria transplant baby."
Liang Xiaoyan introduced that mitochondria are the structures that make up energy in cells. Cells, fats, and amino acids are all finally oxidized in the mitochondria and release energy. It can be called an “energy factory†of cells. The technique of “injection of autologous bone marrow cell mitochondria into oocytes†is to extract the mitochondria in the mother’s own bone marrow cells and inject them into the embryos, which can improve the quality of embryonic development and improve the survival rate of embryos.
The difficulty of this technology lies in the preparation of mitochondria and the precise dose injection. The oocyte is the largest cell in the human body but it is very fragile and requires careful care. Injecting a therapeutic dose of mitochondria into the oocyte requires both the purity and concentration of the extracted mitochondria and the volume of the injection that does not affect the continued development of the oocyte.
Liang Xiaoyan stated that in the process of primary infertility or conventional IVF treatment, repeated embryos are of poor quality and a large number of embryo fragments have no transplantable embryos; at 37 years of age, more than 6 eggs were obtained, but repeated failures and poor embryo quality Patients can try this technique.
On the 13th day of pregnancy, ultrasound found that small U.S. cervical incompetence combined with placenta previa has a high risk of miscarriage and bleeding. In order to keep the baby, the Gao Yu team, director of obstetrics department of Zhongshan Sixth Hospital, had done a minimally invasive cervical cerclage for Xiaomei to prevent baby abortion and to perform caesarean section on the pre-production day.
Since the baby received maternal autologous bone marrow cell mitochondrial injections in the oocyte during the embryonic period, the paediatric department paid special attention to the energy supply in the infant. For babies, there is an alert for insufficient energy supply in the body, such as symptoms of high blood lactate levels. Medications are used to regulate metabolic processes, and milk intake is gradually increased to supplement energy for infants.
15 days later, the hard-won world’s first “mitochondria transplanted baby†finally recovered completely.
Experts stated that the birth of the world’s first “mitochondria transplant baby†was a historic breakthrough, and its reference value for scientific research was immeasurable. We hope that in the future, mitochondrial transplantation technology will bring new hope to more infertile patients. (Cai Min婕 Jian Wen Yang)
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