Nowadays, many researchers believe that the field of electrical stimulation therapy is expanding, and the pulse stimulation of the vagus nerve or other peripheral nerves may provide treatment for many diseases such as diabetes, hypertension, cardiovascular disease, metabolic disease and autoimmune diseases.
Katrin is a 70-year-old fitness instructor living in Amsterdam who joined a clinical trial five years ago. Under her neck is an implanted device that emits electrical impulses when exposed to external magnets to improve her rheumatoid arthritis (an autoimmune disease) by stimulating the vagus nerve.
This clinical trial suggests that more than two decades of research on the relationship between the nervous and immune systems has entered a new era.
In 1998, researchers who were investigating an experimental drug called CNI-1493 stumbled upon the direct injection of the drug into the rat brain compared to intravenous injection, which was more effective in reducing systemic TNF-α in rats. The level of tumor necrosis factor, an inflammatory factor marker, inhibits the inflammatory response.
As a result, the researchers speculated that CNI-1493 may be a signal transduction to nerve cells that affects the immune system's response. Subsequent experiments have shown that by cutting off the nerve, the effective action of the drug will also disappear. Moreover, mice treated with electrical pulse stimulation can effectively antagonize drug-induced septic shock by reducing the level of TNF-α.
This shows that in addition to regulating the contraction of the heartbeat, respiratory and digestive tract muscles, the vagus nerve can also control inflammation. This finding greatly expands the therapeutic field of vagal nerve stimulation, meaning that the technology may be able to replace the drug to achieve the same or better therapeutic effect.
So what is the molecular mechanism behind this?
Researchers use the neurotransmitter inhibitors or damage vagus nerve fibers at different locations to determine where and how the electrical stimulation works. These experiments show that when the vagus nerve is shocked, the pulse signal is transmitted to the abdomen and then through another nerve fiber into the spleen.
This nerve fiber communicates directly with the T cells in the spleen by releasing the neurotransmitter, norepinephrine. The interface between neurons and T cells is similar to the synapse between two nerve cells, and T cells act like neurons.
Another neurotransmitter, acetylcholine, released by T cell activation binds to macrophages in the spleen, thereby inhibiting the production of inflammatory proteins by macrophages and suppressing inflammation.
This is undoubtedly a surprising discovery. However, long before this, researchers have observed neuronal-T cell synaptic structures in different organs of various animals. The difference is that this type of neuron belongs to the sympathetic nerve.
Does the solar PTZ Camera System Kits work well
In fact, there are no network and no electricity cameras, but they have certain limitations. The working time of a camera with batteries or external solar panels is limited.Monitoring without network means that mobile phones and cameras can only be seen within a certain range of 5~10 meters.
Therefore, no network and no power is just a gimmick. We must pay attention to distinguish when buying.
Is the Solar Camera easy to use
Jiajie intelligent surveillance camera is very good
Advantages and disadvantages of solar monitoring
Probably.
Generally, offline display has the following two conditions.
One is that the installed 4G card has no traffic and cannot provide network connection for monitoring;
The other is that there is a problem with the signal receiving device, which makes it unable to connect to the network. Therefore, the user can access the APP connected to the monitor to check whether there is still traffic on the 4G card. If there is still traffic, there is a problem with the monitoring; If there is no traffic, the renewal fee can continue to be used.
Which is the best solar Outdoor Camera
It may be that the poor contact of the power plug causes power on, heating and power failure, or it may be that the camera's internal control motherboard fails, causing power on for several minutes and automatic power off protection.
The camera works continuously, and the internal chip may overheat, which also exists in many SLR cameras. Some cameras impose time limits on continuous shooting. Centralized power supply with high-power switching power supply
Disadvantages of camera solar power supply
The main advantages of solar photovoltaic power generation are:
(1) Simple structure, small and light volume;
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The main disadvantages of solar photovoltaic power generation are:
(1) Low solar energy density and large coverage area;
(2) Photovoltaic power generation is intermittent and random;
(3) Solar energy resources in various regions are not available, so photovoltaic power generation is highly regional.
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