Release date: 2018-05-14
A recent study by researchers at Washington State University showed that state-of-the-art medical technology may still require the help of some traditional therapies. The WSU team developed a 3D printed ceramic stent for bone tissue regeneration and found that when the stent is coated with naturally occurring compounds in turmeric powder, bone regeneration capacity can be increased by 30% to 45%. The project was funded by the National Institutes of Health and led by Professors Susmita Bose, Herman and Britta Lindholm.
As an indispensable flavor of various curries and other dishes, turmeric has long been highly regarded. The flavor extracted from the root is mainly composed of curcumin, which has antioxidant, anti-inflammatory and bone-enhancing capabilities, and also helps prevent various cancers. Turmeric has been used as a drug for centuries, especially in Asian countries, but it is usually taken orally, which is not the most effective way to absorb curcumin. The project is able to directly exploit the advantages of curcumin to achieve more effective results.
The 3D printed bone scaffold is made of a biocompatible ceramic material similar to the materials currently used for tissue regeneration studies. These scaffolds are implanted into cells, and the cells gradually fuse together to form new tissue, depending on the environment in which they are located. A problem that affects many of the bone regenerative drugs currently used to treat osteoporosis and other diseases is the unbalanced remodeling cycle that they may produce in natural bone, as well as the poor quality bone that can be formed.
The research team decided to try to use the naturally occurring compounds in turmeric to stimulate bone growth. They encapsulate curcumin in a hydrophilic polymer, which is a macromolecule, so over time, curcumin can be gradually released from the ceramic scaffold. Coating 3D printed stents with this organic compound has been very successful. Studies have shown that it increases the survival and proliferation of new bone cells and blood vessels in surrounding tissues while accelerating the healing process.
Researchers are also investigating other natural remedies, including compounds from aloe vera, saffron, vitamin D, garlic, oregano and ginger. Bose focuses on compounds that may contribute to bone disease, including those that promote bone growth or have anti-inflammatory, infection-control or anti-cancer properties. (Compiled from 3ders.org)
Source: Tiangongshe
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