Release date: 2017-12-08
The immune checkpoint is a protective molecule in the human immune system, which acts like a brake to prevent inflammatory damage caused by excessive activation of T cells. The miraculous effect of cancer immunotherapy makes the immune checkpoint molecule PD-1 widely known.
Blocking tumor cells to block the PD-1/PDL-1 pathway of T cells can restore the sensitivity of the immune system to tumor cells. A new study published in Nature on October 7 found that PD-1 is also a "switch" in T cells that controls its own reproduction, a feature that can be used to treat lymphatic cancer in the immune system.
Causes of T cell non-Hodgkin's lymphoma
In vivo, T cells are usually responsible for detecting and killing cancer cells. However, problems arise when the T cells themselves produce defects in the genome. If the defect affects the genomic region responsible for cell growth, the T cell itself can become an uncontrollable dividing tumor cell. This is why T-cell non-Hodgkin's lymphoma occurs.
This aggressive lymphoma treatment rate is very low. Professor Jürgen Ruland and his team are studying the molecular mechanisms of these cancers for more effective treatment.
PD-1 plays a switching role in T cell self-reproduction
The scientists found that defective T cells have an emergency shutdown switch to further confirm that protein PD-1 can shut down defective T cells at an early stage, preventing them from becoming tumor cells. This is the first time researchers have discovered PD-1 in a mouse model of T cell non-Hodgkin's lymphoma.
This finding also explains the mechanism by which PD-1 genes are activated when a proto-oncogene responsible for cell growth activity is defective, thereby inhibiting the effects of these genes with additional proteins. Therefore, it acts to turn off the switch to prevent uncontrolled growth of defective T cells. The anti-cancer effect of immunological checkpoint inhibitors is to inhibit T cells' external signals and activate T cells; this newly discovered switch is a switch that activates PD-1 to turn off T cell proliferation by targeting T cell self-deficiencies.
Patient data and hope for medication
By investigating the genetic dataset of 150 patients, scientists have also successfully solved the problem of why many T-cell non-Hodgkin's lymphomas are so aggressive.
According to Tim Wartewig, the first author of the study, "Based on our previous results, we deliberately closely followed PD-1. In more than 30% of patients, the genomic region producing PD-1 has changed. This catastrophic The consequence is cancer, PD-1 no longer acts as an 'emergency shutdown' switch, and defective T cells multiply out of control."
Professor Jürgen Ruland said: "These patients can reverse the loss of PD-1 signal by drug therapy, thereby destroying tumor cells. This type of drug is already present in other forms of cancer. In our opinion, T cells should also be considered. Non-Hodgkin's lymphoma medication." Scientists recommend studying individual differences in tumors before deciding which drug to take.
Reference material
1) PD-1 is a haploin sufficient suppressor of T cell lymphomagenesis
2) Important tumor suppressor discovered in immune cells
Source: Bio-Exploration
Video door-phone (also known as video door entry or video intercom) is a stand-alone intercom system used to manage calls made at the entrance to a building (residential complex, detached family home, workplace, etc.) with access controlled by audiovisual communication between the inside and outside. The main feature of video door entry is that it enables the person indoors to identify the visitor and, if (and only if) they wish, engage in conversation and/or open the door to allow access to the person calling.
The following product is the best-selling and most cost-effective video door phone in our factory,
It adopts a 4.3-inch high-definition screen and an aluminum alloy body, and is equipped with led light. It has night vision function and can clearly monitor the outdoor environment and make video calls with visitors even in the dark; physical button operation, classic design, no Easily leave fingerprints and keep your device clean and tidy. It can be used in multi-apartment systems.
The product parameters of 888QZJ4A are for your reference:
1. 4.3 inch 720 HD display TCP/IP Intercom system
2. Calling, intercom, unlocking, monitoring
3. High quality aluminium alloy frosted panel + physical buttons
4. Digital camera, stable and clear image shooting
5. Night vision and bright light compensation function
6. Full duplex voice intercom, comparable to ordinary telephone intercom
7. Elevator linkage function, connect the security system
8. LINUX system platform architecture, system simplification and stability
9. LPDDR3 1 GB memory, standard EMMC 8 GB storage expandable
10. RJ45 standard ethernet interface all-digital design
11. Low power consumption technology solution, saving energy and long life span
12. Dimension:400*140*51(mm)
13. Install method : Wall/flush install (390*130*46 mm)
14. Image/video advertising playback (advertising can be customized)
15. Door opening:IC/ID card/ password/call the Indoor Monitor or center management machine unlock
We are a factory specializing in the production, manufacture and research and development of video door phones for 11 years. We are located in the beautiful coastal city - Zhuhai. We have our own R&D team, we can provide professional products and services. We have different systems of video door phone for different customers and markets, for example, IP video door phone, 2-wire audio door phone, 4-wire video door phone and wireless doorbell, if you are interested, please feel free to contact me, I can send our catalog to your email.
Multi Video Door Phone,Video Door Phone Intercom System,Video Phone Doorbell,Video Door Calling System
Zhuhai Mingke Electronics Technology Co., Ltd , https://www.mingke-tech.com