Is this magic or coincidence? It has been previously found that patients with Alzheimer's disease rarely have certain cancers, such as lung cancer, colon cancer and prostate cancer, but the incidence of brain cancer is greatly increased. Conversely, lung cancer patients have a lower chance of getting dementia. why? What is the connection between this?
A study conducted by the National Cancer Research Center (CNIO) in Spain studied the molecular similarities and differences between these horrible diseases from the level of gene expression, at least partly explaining the reversal of Alzheimer's disease (commonly known as Alzheimer's disease) and lung cancer. Association, and a direct positive association with glioblastoma. Details of the study, published in the recent issue of Scientific Reports, entitled "Molecular Hypothesis Explain the Positive and Negative Correlation Between Alzheimer's Disease, Glioblastoma and Lung Cancer" (A molecular Hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer).
The researchers used a systematic meta-analysis of transcriptomic gene expression data from more than 1,000 tissue samples from patients to compare the dysregulated genes in these diseases and found that 198 genes were functionally functioning under three disease conditions. Change. Among them, 112 genes have similar changes in Alzheimer's disease and glioblastoma, and have opposite changes in lung cancer.
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