Tumor sticking can help prevent cancer
July 01, 2019 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; Researchers at the Massachusetts Institute of Technology found that a special protein can "give" anti-cancer cytokines into tumor tissue like "tumor gluing" to enhance anti-cancer effects. It is expected to develop new models based on this. Precision anti-cancer therapy.
The study, recently published in the journal Science and Translational Medicine, shows that a protein called photoglycan can “restrict†cytokines to solid tumor tissue and prolong its killing like nylon hooks. Time to destroy the tumor, reducing its damage to healthy tissue.
Cytokines are proteins released by immune cells and have anti-cancer effects in combination with other immunotherapies, but they kill both tumor tissue and normal body tissues. Previously, oncologists attempted to inject cytokines directly into tumors, but the protein "overflows" after a few minutes.
The researchers selected two interleukin-2 and interleukin-12 cytokines that stimulate immune cell responses and injected them into melanoma in mice. The results showed that the mice could not survive with cytokine treatment alone; the cytokine was combined with other immunotherapy, and the survival rate of the mice was slightly improved; using cytokines combined with photoprotease and combined with other immunotherapy, More than 90% of the mice survived.
The first author of the paper, Nur Mumming, said that these combination therapies have synergistic effects, coupled with the help of photoproteoglycans, can fully play the utility of combination therapy. The research team next plans to try to apply this "tumor gluing" to other anti-cancer therapies.
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